Alexander Shulgin said this quote
“ I don't know if you realize this, but there are some researchers - doctors - who are giving this kind of drug to volunteers, to see what the effects are, and they're doing it the proper scientific way, in clean white hospital rooms, away from trees and flowers and the wind, and they're surprised at how many of the experiments turn sour. They've never taken any sort of psychedelic themselves, needless to say. Their volunteers - they're called 'subjects,' of course - are given mescaline or LSD and they're all opened up to their surroundings, very sensitive to color and light and other people's emotions, and what are they given to react to? Metal bed-frames and plaster walls, and an occasional white coat carrying a clipboard. Sterility. Most of them say afterward that they'll never do it again. ”