Andrew B. Newberg said this quote

“ The brain is a stubborn organ. Once its primary set of beliefs has been established, the brain finds it difficult to integrate opposing ideas and beliefs. This has profound consequences for individuals and society and helps to explain why some people cannot abandon destructive beliefs, be they religious, political or psychological. ”

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We can't tell you the origin of the experience. But we can tell you the brain does appear to be built to have these [mystical] experiences. There are examples of people reaching similar states, spontaneously. But for the most part, it takes work. Meditation and these powerful prayer experiences require dedication and practice. But people have figured out how to do this, and the question is, 'What is the source of that experience?' The answer is, 'We don't know.' Science doesn't really have an answer for you.

~ Andrew B. Newberg

Andrew B. Newberg 2011 Meditation Neurotheology Prayer Science Vs Religion The Great Work