Anne Rice said this quote

But to think there was meaning, a scheme to things, well, that was quite beyond her philosophical reach. She feared as she always had, that all that was ever meant was loneliness, hard work, striving to make a difference when no difference could possibly be made. It was like dipping a stick into the ocean and trying to write something – all the little people of the world spinning out little patterns that lasted no more than a few years, and meant nothing at all.