John Rush said this quote

“ Methods of detoxifying and processing plants for human use are known throughout the world, and include a variety of techniques, including dehydration, application of heat, leaching, and fermentation, among others (Johns and Kubo 1988). While it is difficult to trace the origins of these methods, or to answer the questions of how certain groups learned to detoxify and process useful plants in their environment, to make a blanket claim that certain cultures were incapable of discovering plant properties, and the methods necessary for rendering them same and useful, seems naive at best. ”

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Inhaling fumes directly from burning foliage, either in a confined space such as a cave or a tent, or scooping up and breathing in the vapors from psychoactive plant materials scattered on a bowl full of hot coals, must be an extremely ancient practice. Herodotus's account from the fifth-century BCE, describing the use of small tents by the Scythians (a northwestern Iranian tribe) for inhaling the smoke of cannabis, is probably the most famous account that confirms the antiquity of the use of cannabis as a ritual intoxicant.

~ John Rush

The effect of hallucinogenic mushrooms on the user's experience and behavior depends in part on his or her personality and genetic predisposition, which can vary to a great extent from person to person. As symptoms of psychiatric disorders can sometimes be elicited after one-off use, people with a genetic tendency to depression or psychosis should be discouraged from using psychoactive mushrooms.

~ John Rush

The growth patterns of mushrooms are difficult to view since they come and go so quickly, appearing and disappearing overnight as if by magic. Their apparent lack of seed is another feature that was likely observed by early peoples who encountered them, perhaps providing further mystery as to the origin of the strange organisms.

~ John Rush

Several centuries ago it was believed that the fly agaric, combined with the bufotenin–containing mucus of toads, was an ingredient of witches' brews, which made flying on their broomsticks possible. Even Santa Claus and Father Christmas are connected to Fly Agaric and their reindeer, which, by the way, like their portion of fly agarics and 'living' water.

~ John Rush