Tom Wolfe said this quote

Loneliness wasn't just a state of mind, was it? It was tactile. She could feel it. It was a sixth sense, not in some fanciful play of words, but physically. It hurt... it hurt like phagocytes devouring the white matter of her brain. It wasn't merely that she had no friends. She didn't even have a sanctuary in which she could simply be alone.

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