David Pearce said this quote

A lot of people recoil from the word drugs - which is understandable given today's noxious street drugs and their uninspiring medical counterparts. Yet even academics and intellectuals in our society typically take the prototypical dumb drug, ethyl alcohol. If it's socially acceptable to take a drug that makes you temporarily happy and stupid, then why not rationally design drugs to make people perpetually happier and smarter? Presumably, in order to limit abuse-potential, one would want any ideal pleasure drug to be akin - in one limited but important sense - to nicotine, where the smoker's brain finely calibrates its optimal level: there is no uncontrolled dose-escalation.

~ David Pearce

Too many of our preferences reflect nasty behaviours and states of mind that were genetically adaptive in the ancestral environment. Instead, wouldn't it be better if we rewrote our own corrupt code?

~ David Pearce

The Hedonistic Imperative outlines how genetic engineering and nanotechnology will abolish suffering in all sentient life. This project is ambitious but technically feasible. It is also instrumentally rational and ethically mandatory. The metabolic pathways of pain and malaise evolved only because they once served the fitness of our genes. They will be replaced by a different sort of neural architecture. States of sublime well-being are destined to become the genetically pre-programmed norm of mental health. The world's last aversive experience will be a precisely dateable event.

~ David Pearce

It's not that there are no differences between human and non-human animals, any more than there are no differences between black people and white people, freeborn citizens and slaves, men and women, Jews and gentiles, gays or heterosexuals. The question is rather: are they morally relevant differences? This matters because morally catastrophic consequences can ensue when we latch on to a real but morally irrelevant difference between sentient beings.

~ David Pearce