Hugh Laurie said this quote

“ The sexual mechanisms of the two genders are just not compatible, that’s the horrible truth of it. (...)This is a truth we dare not acknowledge these days - because sameness is our religion and heretics are no more welcome now than they ever were - but I’m going to acknowledge it, because I’ve always felt that humility before the facts is the only thing that keeps a rational man together. Be humble in the face of facts, and proud in the face of opinions, as George Bernard Shaw once said. He didn’t, actually. I just wanted to put some authority behind this observation of mine, because I know you’re not going to like it. ”

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I would cling to unhappiness because it was a known, familiar state. When I was happier, it was because I knew I was on my way back to misery. I've never been convinced that happiness is the object of the game. I'm wary of happiness.

~ Hugh Laurie

I was shown into a room. A red room. Red wallpaper, red curtains, red carpet. They said it was a sitting-room, but I don’t know why they’d decided to confine its purpose just to sitting. Obviously, sitting was one of the things you could do in a room this size; but you could also stage operas, hold cycling races, and have an absolutely cracking game of frisbee, all at the same time, without having to move any of the furniture.It could rain in a room this big.

~ Hugh Laurie

This was the tricky bit. The really tricky bit, trickiness cubed.

~ Hugh Laurie

We want different things. Men want to have sex with a woman. Then they want to have sex with another woman. And then another. Then they want to eat cornflakes and sleep for a while, and then they want to have sex with another woman, and another, until they die. Women,’ and I thought I’d better pick my words carefully when describing a gender I didn’t belong to, ‘want a relationship. They may not get it, or they may sleep with a lot of men before they do get it, but ultimately that’s what they want. That’s the goal. Men do not have goals. Natural ones. So they invent them, and put them at either end of a football pitch. And then they invent football. Or they pick fights, or try and get rich, or start wars, or come up with any number of daft bloody things to make up for the fact that they have no real goals.’‘Bollocks,’ said Ronnie.‘That, of course, is the other main difference.

~ Hugh Laurie